John Laffey

John Laffey


John Laffey is Professor of Anaesthesia at the School of Medicine of the National University of Ireland, Galway and a Consultant in Anaesthesia and Intensive Care Medicine at Galway University Hospitals. His basic and translational research is focused on critical illnesses, particularly finding therapies for sepsis and acute respiratory distress syndrome.

Professor Laffey’s major research focus is the investigation of the therapeutic potential of cell and gene-based therapies for critical illnesses, particularly sepsis and acute respiratory distress syndrome. His research programme spans the spectrum from basic and translational research to understand mechanisms of critical illness and develop potential therapies, through to clinical translation and clinical trials and to understanding the epidemiology of critical illnesses. He has an interest in development and application of novel technologies for organ support and therapeutic drug delivery in the critically ill and in the application of data analytic approaches to this population.

The major clinical targets for Professor Laffey’s research programmes are critical illnesses, particularly sepsis and acute respiratory distress syndrome.

Professor Laffey’s achievements include: Co-Principal Investigator for LUNG SAFE (Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE) Study, the largest epidemiologic study of severe respiratory failure undertaken to date [JAMA 2016, Feb 23;315(8):788-800]  and Co-Principal Investigator for WEAN SAFE (WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE, a large-scale epidemiologic study of weaning from mechanical ventilator support.

Professor Laffey was Principal Investigator for Ireland in the HARP-2 clinical trial of Simvastatin for ARDS. This was the first investigator-led international multi-centre randomized clinical trial in critically ill patients in Ireland and the United Kingdom, and published in 2014 [N Engl J Med. 2014 Oct 30;371(18):1695-703]. He is a founder and lead investigator of the Lung Biology group at NUI Galway.

Professor Laffey has published over 200 peer-reviewed publications/editorials and delivered over 100 international invited lectures.

He has secured €7,000,000 in peer-reviewed funding as PI (20 grants); €1,750,000 in non-exchequer funding; secured approx €25,000,000 Co-PI/Collaborator in last 10 years.

Prof. Laffey is Deputy chair of Irish Critical Care Trials Group, previously, Deputy chair of Acute Respiratory Failure Secretion of European Society of Intensive Care Medicine. He is Founding co-chair of the Critical Illness and Injury Research Centre (CIIRC) at St Michael’s hospital, Toronto. He holds the following positions:

Member, Editorial Board of Perioperative Medicine

Member, Editorial Board of Intensive Care Medicine Experimental

Member, Anesthesia and Perioperative Medicine Section, Faculty of 1000 Medicine