INSIST

INSIST

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Abstract

Stroke is the number one cause of disability in the Western world and the 3rd most common cause of death. Despite new treatment options with intra-arterial thrombectomy, still 2 out of 3 patients still have a poor outcome. The main goal of INSIST is to advance treatments of ischemic stroke and its introduction in clinical practice by realizing in silico clinical stroke trials in which stroke and treatment are modeled. We will generate virtual populations of stroke patients, generate and validate in silico models for intra-arterial thrombectomy, thrombosis and thrombolysis, and microvascular perfusion and neurological deterioration after stroke, and integrate the in silico models to realize an in silico clinical stroke trial. We are uniquely positioned by the availability of a large pool of clinical, imaging, histopathological, and outcome data from multiple recently finalized stroke trials, a large registry (totaling 4500 patients), and new trials that will start later this year (totaling 2500 patients)

Consortium

Academisch Medisch Centrum bij de Universiteit van Amsterdam (Coordinator), UNIVERSITEIT VAN AMSTERDAM, University of Oxford, Neuravi LTD, NUI Galway, Katholieke Universiteit Leuven, Politecnico Di Milano, Universite De Geneve, Institut De Recherches Internationales Servier, M.V. Lomonosov Moscow State University.

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