Biomaterials and Drug Delivery
Dr Eoin O’Cearbhaill
biometals; medical device design; bioabsorbable bulk metallic glass, microneedle
Magnesium-alloy-based implants have been investigated for their potential to absorb in the body after fulfilling their mechanical role. However, they often dissolve too fast which impacts on their functional performance and wound healing response; hydrogen evolves, as a product of corrosion, too quickly to be absorbed by the body, leading to gas bubbles evolving near the device. A potential solution is to use a Mg-based Bulk Metallic Glass (BMG) alloy that is corrosion resistant (owing to its amorphous nature and lack of grain boundaries). In collaboration with Dr. David Browne, our research seeks to develop a bioresorbable Mg-based BMG and to evaluate its biocompatiblilty and resorption rates in vitro and in vivo for medical device applications.