Biomaterials and Drug Delivery
Professor Larry Egan
fistula; Crohn’s disease; bioengineering; biomaterials
Perianal fistulas, which are pathological connections between the skin adjacent to the anus and the upper anal canal, affect many Crohn’s disease patients and cause great suffering. Current treatment of perianal fistulas is often ineffective. In our research we pursue a novel approach designed to better treat this problem, by developing a combination medical device that provides drainage to the fistula tract and delivers a potent drug locally to the diseased area. This innovation will be the first locally delivered therapy that reverses pathological processes that cause chronic perianal fistulas while avoiding the side effects of systemic drug therapy.