Glyco and Protein Engineering
Dr Michelle Kilcoyne
host-pathogen interactions; immune response; functionalisation; signalling
The Carbohydrate Signalling Group is interested in elucidating carbohydrate-mediated host-pathogen interactions. Capsules shield pathogenic bacteria from immunosurveillance by the host immune system but specific interactions and responses are not well understood. Implanted medical device materials often elicit an immune response from host tissue and are subject to device infections, which can be difficult to treat and clear. Developing a better understanding of the host-pathogen interactions that allow bacteria to avoid the host immune system, in particular focusing on complement activation pathways and subsequent cell responses, could lead to novel strategies in avoiding immune response to implanted medical device materials.