Glyco and Protein Engineering
Professor Lokesh Joshi
glycobiology; extracellular matrix; carbohydrates; polysaccharides; glyco-analysis; affinity-based analysis
Through carbohydrate-focused approaches, the Advanced Glycoscience Research Cluster (AGRC) is progressing the knowledge and future functionalization of cells, materials and devices with the ultimate goal of engineering glyco-enabled surfaces. Our research targets the refinement and testing of extracellular matrix (ECM), examining and profiling the vital attributes provided by oligo- and polysaccharides and their interactions with ECM components. It is anticipated that through the identification and targeting of discrete glycan motifs, suitable ECM models will be produced for enhanced biological interactions, assisting in rational engineering strategies for molecular and surface modification of materials, cells, tissues and implantable devices.