Professor Paul Murphy

Professor Paul Murphy

Established Professor of Chemistry
NUI Galway

lectin inhibitors; oligosaccharides; synthesis; carbohydrates

We are interested in the design and synthesis of lectin inhibitors as tools for study in medical device research. Such lectin inhibitors can be relevant for the prevention of biofilms in medical devices. They can also be used to study the role of lectins in biological processes related to regenerative medicine, for example. Lectin inhibitors or ligands can be used for drug delivery, including potentially for targeting vaccines to antigen presenting cells, such as dendritic cells. These inhibitors can include oligosaccharides or multivalent variants of such oligosaccharides.

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Recent references from the Murphy group:

Molecules 2016, 21, 629; http://dx.doi.org/10.3390/molecules21050629

Histochemistry and Cell Biology, 2015, http://link.springer.com/article/10.1007/s00418-015-1383-6

Organic and Biomolecular Chemistry, 2015, 13, 4190–4203; http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00048C

Tetrahedron, 2015, http://dx.doi.org/10.1016/j.tet.2015.07.020