Tissue Engineering & Regenerative Medicine
Dr Martin O'Halloran
medical devices; Primary Aldosteronism; hypertension; ablation
High blood pressure is a global health problem that accounts for more than 9.4 million deaths every year, and affects over 1 billion people worldwide. Hypertension directly causes approximately 25% of heart attacks in Europe and, in its progressed form of cardiovascular disease, is responsible for 42% of all deaths across Europe annually. In the last ten years, Primary Aldosteronism (PA) has been recognised as the most common curable cause of hypertension. PA is thought to account for up to 18% of all cases of hypertension within the population and is caused by benign shallow hormone-eluding adenomas on the surface of the adrenal gland. The disease provide a clear motivation for a safer, less invasive and more effective treatment for PA and associated hypertension. We aim to develop a novel microwave ablation system that is capable of identifying and destroying shallow adrenal adenomas to combat PA, critically whilst preserving the functional tissue of the remaining adrenal gland.