Tissue Engineering & Regenerative Medicine
Professor Matthew Griffin
diabetes; kidney disease; vesicles; cell biology; systems biology
In keeping with my long-standing research interests in kidney disease, the immune system and regenerative therapies, we are focused on: (a) profiling mechanisms of renal epithelial cell injury under diabetic conditions, (b) defining how these mechanisms are influenced by interaction with shed vesicles (“exosomes”) from immune cells or regenerative stem cells and (c) harnessing this information to design targeted interventions to ameliorate progressive renal tubular injury in people with diabetes. Researchers joining my team will have access to relevant cell culture models, clinical samples, resources for vesicle isolation and characterization, imaging platforms, profiling technologies and an international collaborative network.