Tissue Engineering & Regenerative Medicine
Professor Tim O'Brien
mesenchymal stromal cells; endothelial progenitor cells; critical limb ischemia; fundamental stem cell biology
The aim of my research is to achieve a better understanding of the fundamental biology of stem and progenitor cell populations, and how this biology can be altered in disease states such as diabetes. My group also has a strong translational focus and to this end, we aim to use these cell populations (MSCs, EPCs, CACs), produced to GMP grade (unaltered, modified and selected states), as therapeutic agents in Phase1/2 patient clinical trials for the treatment of diabetic complications such as wound healing, kidney disease and critical limb ischemia.