Tissue Engineering and Regenerative Medicine

Immunology of stem cells

Tissue Engineering and Regenerative Medicine is a key area of research at CÚRAM with a goal of finding solutions to chronic health problems and conditions of unmet medical need. Scientific advances in stem cells, gene therapy, biomaterials, medical device technology, growth and differentiation factors, and biomimetic environments have created unique opportunities to fabricate tissues in the laboratory from combinations of engineered extracellular matrices ("scaffolds"), cells, and biologically active molecules. In addition, use of these technologies to develop reparative and regenerative approaches in vivo is a major goal. Engineered matrices have taken a variety of forms such as injectable hydrogels, films, nanofibers, and nanostructured format using nanoprinting technologies.

With a focus on biomimetics and regenerative medicine, CÚRAM is developing innovative approaches, assays and tools for comprehensive and accurate analysis of complex biological systems and their interaction with medical devices and associated therapeutics. CÚRAM has a translational research focus utilizing GMP manufactured cells in early phase clinical trials in diseases such as diabetic vascular complications and osteoarthritis.  This is enabled by critical infrastructure for GMP cell manufacturing and a specialized clinical research facility.