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BMT Publications

Publications

OpenAire: https://explore.openaire.eu/search/project?projectId=corda__h2020::5a3334915e2c4f5e83127a344f15718f

Journal Publications 2019

  • Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson’s disease models. Buket Ucar, Christian Humpel. Brain Research Bulletin, July 2019, Pages 86-95. https://doi.org/10.1016/j.brainresbull.2019.04.012
  • A Window into the brain: Tools to assess preclinical efficacy of biomaterials-based therapies on central nervous system disorders. Juhi Samal, Ana Lucia Rebelo, Abhay Pandit. Advanced Drug Delivery Reviews. Jan. 2019. https://doi.org/10.1016/j.addr.2019.01.012

Journal Publications 2018

  • Mitral cells and the glucagon-like peptide 1 receptor: The sweet smell of success? Enrico Bagnoli, Una FitzGerald.  DOI: 10.1111/ejn.14115
  • Encapsulation of young donor age dopaminergic grafts in a GDNF-loaded collagen hydrogel further increases their survival, reinnervation, and functional efficacy after intrastriatal transplantation in hemi-Parkinsonian rats. Niamh Moriarty, Sílvia Cabré, Verónica Alamilla, Abhay Pandit, Eilís Dowd. European Journal of Neuroscience.  doi/abs/10.1111/ejn.14090
  • Collagen for brain repair: therapeutic perspectives. Christian Humpel, Buket Ucar. Neural Reg. Res. 10.4103/1673-5374.230273
  • Simple generation of a high yield culture of induced neurons from human adult skin fibroblasts. Shelby Shrigley, Karolina Pircs, Roger A. Barker, Malin Parmar, Janelle Drouin-Ouellet.  Journal of Visualized Experiments. 10.3791/56904, 10.17863/CAM.18215 
  • The unlikely partnership between LRRK2 and α- synuclein in Parkinson's disease. N. Cresto, C. Gardier, F. Gubinelli, M.-C. Gaillard, G. Liot, A. B. West, E. Brouillet. European Journal of Neuroscience. 10.1111/ejn.14182 
  • Simple generation of a high yield culture of induced neurons from human adult skin fibroblasts. doi:10.3791/56904 

Journal Publications 2017

  • Direct reprogramming of resident NG2 glia into neurons with properties of fast spiking parvalbumin-containing interneurons. Pereira, M, Birtele, M, Shrigley, S., Benitez, J.A., Hedlund, E., Parmar, M., Ottosson, D.R.  Stem Cell Reports. 10.1016/j.stemcr.2017.07.023
  • Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices. Bettina M. Foidl, Buket Ucar, Alina Schwarz, Ana L. Rebelo, Abhay Pandit, Christian Humpel. Journal of Neuroscience Methods. 10.1016/j.jneumeth.2017.12.003

Conference presentations and other publications: https://zenodo.org/communities/brainmattrain-676408/ 

2019

  • Delivery of an Injectable Biomaterial to the Striatum- a Computational Analysis.
  • Computational Analysis of Intrastriatal Delivery of Collagen.

2018

  • Mapping alteration of dopaminergic neurons in a rat model of Parkinson Disease through the comparison of two presynaptic PET tracers.‌
  • Characterisation of two genetic rat models of Parkinson Disease through two presynaptic PET tracers; [18F]-LBT999 and 6-[18F]fluoro-L-m-tyrosine‌.
  • Mapping alteration of dopaminergic neurons in a rat model of Parkinson Disease through the comparison of the presynaptic PET tracers, [18F]-LBT999 and 6-[18F]fluoro-L-m-tyrosine.‌
  • Flow simulation of a natural polymer in a syringe-needle delivery device.
  • An injectable Collagen Hydrogel as a delivery system for Parkinson's disease.
  • α-syn and LRRK2: a synergistic relationship?
  • In vivo characterisation of an IL-10 rich collagen hydrogel scaffold for Parkinson’s disease.
  • Encapsulation of young donor age dopaminergic grafts in a GDNF-loaded collagen hydrogel further increases their survival, re-innervation and functional efficacy after intra-striatal transplantation in hemi-Parkinsonian rats.
  • Potential of an injectable IL-10 rich collagen hydrogel for cell transplantation in Parkinson’s disease.
  • Reprogramming of Adult Human Fibroblasts to Dopaminergic Neurons.
  • Therapeutic efficacy of GDNF loaded collagen scaffolds in organotypic brain slices with rotenone-induced PD.
  • DOPAL and the Olfactory Bulb: a novel platform to mimic prodromal Parkinson's disease.
  • DOPAL-Treated Olfactory Bulb Organotypic Slices as a Model of Prodromal Parkinson's Disease.
  • The effect of DOPAL on the bioenergetic performances of primary olfactory bulb mixed cultures.
  • Utility of ventral mesencephalic tissue explants for assessment of neurotrophin-functionalised biomaterial hydrogels in the context of Parkinson’s disease therapeutics.
  • Assessment of neurotrophin-functionalised biomaterial hydrogels using ventral mesencephalic tissue explants in context of Parkinson’s disease therapeutics.
  • Effects of GDF-5-loaded collagen hydrogels after intrastriatal transplantation of ventral mesencephalic cells in a rat model of Parkinson’s disease.
  • Assessment of the efficacy and safety of neurotrophin-functionalised biomaterial hydrogels in a ventral mesencephalic tissue explant model in the context of Parkinson’s disease therapeutics.
  • Flow Simulation of a Natural Polymer in a Syringe Needle Delivery Device
  • Effect of Geometry on Collagen Flow in Constricted Channels for Cell Delivery.
  • Towards an Effective, Needle Based Delivery Device for Parkinson’s Disease: a Simulation Study on the Impact of Needle Diameter.
  • Flow Simulation of a Collagen Solution in Syringes with Different Geometries.
  • Computational Analysis of Collagen Delivery to the Striatum.
  • Electrophysiological properties of long term cultured human induced neurons.
  • Proteomic profiling of striatal tissue of a rat model of Parkinson’s disease after implantation of collagen-encapsulated mesenchymal stem cells.
  • Promoting functional maturation of induced human neurons.
  • Inflammation biomarker discovery in Parkinson's disease and multiple system atrophy.
  • A Method for the Characterisation of N-glycome from Brain Tissue Glycoproteins.
  • Carbohydrate-Functionalised Collagen Hydrogels for Cell Delivery in Neural Environment.
  • Optimisation of a Carbohydrate-Functionalised Collagen Gel for Ventral Mesencephalic Cell Delivery.

2017  

  • Direct Reprogramming of Adult Human Fibroblasts: Generation of Dopaminergic Neurons for Cell-Based Replacement Therapy.
  • Mutant form of C-terminal fragment of LRRK2 increases α-synA53T toxicity in dopaminergic neurons in vivo.‌
  • Optimisation of a collagen-based system for cell delivery to the brain.
  • Olfactory bulb slices as a model of pre-motor Parkinson’s Disease.‌
  • 3D Printing in solid-like liquids for neural tissue fabrication.‌
  • ‌Optimising a hydrogel system for VM cell delivery.‌
  • Towards a complete organotypic model of Parkinson’s Disease.
  • Intra-striatal delivery of anti-inflammatory cytokines encapsulated in an injectable collagen hydrogel. ‌
  • Optimisation of long term culture conditions for human induced neurons.‌
  • Direct neural conversion of adult human fibroblasts – generation of dopaminergic neurons for cell-based replacement therapy.‌
  • Optimisation of a substantia nigra explant system for ex vivo Parkinson’s disease modelling.
  • Kinase domain of LRRK2G2019S is sufficient to trigger neurodegeneration of dopaminergic  neurons and increases alpha-synuclein toxicity in vivo.

 2016

  •  Assessment of the neural biocompatibility of collagen hydrogels using primary cultures prepared from the developing ventral mesencephalon.
  • Towards a complete organotypic model of Parkinson’s Disease.
  • The effect of natural polymers on the viability of cultured brain slices.